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Assignment of the haemophilia B (Factor IX) locus to the q26‐qter region of the X chromosome
Author(s) -
BOYD Y.,
BUCKLE V. J.,
MUNRO E. A.,
CHOO K. H.,
MIGEON B. R.,
CRAIG I. W.
Publication year - 1984
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1984.tb01009.x
Subject(s) - locus (genetics) , haemophilia b , microbiology and biotechnology , metaphase , biology , genetics , somatic cell , x chromosome , restriction enzyme , chromosome , haemophilia a , gene , dna , factor ix , gene mapping , haemophilia
Summary Two independent approaches have provided an assignment for the factor IX (Haemophilia B) locus to Xq26–qter, the distal region of the X chromosome long arm. Cloned DNA sequences of the gene were hybridized to restriction enzyme digests of DNA prepared from a series of somatic cell hybrids containing different X‐chromosomal regions and also in situ to prepared metaphase chromosomes.