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A computer program for constructing a maximum‐likelihood map from linkage data and its application to human chromosome 1
Author(s) -
Wedd N.
Publication year - 1984
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1984.tb00847.x
Subject(s) - locus (genetics) , linkage (software) , chromosome , computer program , maximum likelihood , genetics , genetic linkage , lod score , biology , computer science , gene , mathematics , gene mapping , statistics , programming language
Summary An algorithm is described which attempts to find the maximum likelihood order of the loci on a chromosome using linkage data. It can also use data on locus order if these are available. A computer program which applies this algorithm has been written, and tested on the data for human chromosome 1. The most likely possible order is GDH, PGD, ENO1, Rh, UMPK, Sc, PGM1, AMY, Fy, CAE, 1qh, CMT1, AT3, PEPC.