Premium
Calculation of recurrence risk in the case of ankylosing spondylitis taking into consideration the antigen HLA‐B‐27
Author(s) -
Gömör B.,
Ratkó I.
Publication year - 1984
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1984.tb00837.x
Subject(s) - ankylosing spondylitis , human leukocyte antigen , medicine , hla b , inheritance (genetic algorithm) , antigen , disease , immunology , genetics , biology , gene
Summary The authors have provided a new recurrence risk table of ankylosing spondylitis. The mathematical problem solved was to combine a continuous distribution for polygenic inheritance with a discrete one, HLA‐B‐27 antigen ‘yes’ or ‘no’. Previously the highest probability of recurrence was 0.0785 in the case of an affected mother's son and it increased to 0.1416 when the B‐27 antigen positive affected mother had a B‐27 positive son.