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Immunological and biochemical characterization of the human alcohol dehydrogenase χ‐ADH isozyme
Author(s) -
Adinolfi A.,
Adinolfi M.,
Hopkinson D. A.
Publication year - 1984
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1984.tb00828.x
Subject(s) - isozyme , alcohol dehydrogenase , locus (genetics) , biology , gene , genetics , biochemistry , enzyme , alcohol
Summary 1. The recently identified χ ‐ADH isozyme was purified from human liver and used to raise immune sera. 2. The χ form of ADH showed no structural resemblance to the ADH1, ADH2 and ADH3 (class I) or ADH4 (class II) isozymes, as judged by its immunological properties. 3. χ ‐ADH was found in most human tissues including fetal specimens of 16 weeks gestational age and showed a preference for long chain primary alcohols with a double bond in the β position. 4. We conclude that the locus, designated ADH5 , encoding the χ isozyme has a separate evolutionary origin from the other ADH genes.