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Isozymes of rodent 5‘‐nucleotidase: evidence for two independent structural loci Umph‐1 and Umph‐2
Author(s) -
Swallow D. M.,
Turner V. S.,
Hopkinson D. A.
Publication year - 1983
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1983.tb00965.x
Subject(s) - isozyme , biology , nucleotide , biochemistry , hamster , genetics , gene , microbiology and biotechnology , enzyme
Summary Two distinct isozymes (UMPH‐1 and UMPH‐2) which hydrolyse pyrimidine 5′‐nucleotides have been identified in mouse, rat and Chinese hamster tissues. One of these, UMPH‐1 appears to be specific for pyrimidine 5′‐nucleotides, whereas the other, UMPH‐2 has a broader substrate specificity. UMPH‐1 and UMPH‐2 show differences in their expression in different tissues. The evidence suggests that UMPH‐1 and UMPH‐2 are coded by distinct structural gene loci, UMPH‐1 and UMPH‐2. These isozymes have not been identified in man, and it is suggested that they may have overlapping electrophoretic mobility.