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Bias of the estimated recombination fraction and lod score due to an association between a disease gene a marker gene
Author(s) -
CLERGETDARPOUX F.
Publication year - 1982
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1982.tb01587.x
Subject(s) - recombination fraction , recombination , genetics , biology , gene , fraction (chemistry) , gene mapping , chemistry , organic chemistry , chromosome
Summary An association between a recessive disease gene and a biallelic codominant linked marker is shown to induce some bias in the estimation of the recombination fraction by the lod score method. We demonstrate that ignoring the association may lead to an underestimate of the true recombination fraction and the lod score.