Premium
A monoclonal antibody recognizing a cell surface antigen coded for by a gene on human chromosome 17
Author(s) -
BAI Y.,
SHEER D.,
HIORNS L.,
KNOWLES R. W.,
TUNNACLIFFE A.
Publication year - 1982
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1982.tb01584.x
Subject(s) - chromosomal translocation , monoclonal antibody , antigen , biology , microbiology and biotechnology , chromosome , gene , antibody , karyotype , genetics , cell , somatic cell
Summary The monoclonal antibody, H207 , raised against the human T‐cell‐derived acute lymphoblastic leukaemia line HSB‐2 , recognizes an antigen of apparent molecular weight 125000 which is coded for by the gene, MIC6 , on chromosome 17. Assignment was based on the pattern of reactivity with a panel of somatic cell hybrids. In particular, two hybrids containing only human chromosome 17 or a human translocation chromosome t( 3;17 ) (3pter‐3p11::17p11–17qter) respectively bound H207 , whilst their revertands did not. The H207 antigen has a general tissue distribution but is not found on B‐cell lines and is lacking from some T‐cell lines.