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Genetic polymorphism of coagulation factor XIIIB subunit in Japanese
Author(s) -
NAKAMURA S.,
ABE K.
Publication year - 1982
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1982.tb00712.x
Subject(s) - polymorphism (computer science) , genetics , coagulation , protein subunit , biology , genotype , medicine , gene
SUMMARY Genetic polymorphism of coagulation factor XIIIB subunit in Japanese has been described, using thin‐layer agarose gel isoelectric focusing followed by immunofixation. Phenotypes of factor XIIIB subunit were essentially classified into three common patterns A, B and AB. It is estimated that the phenotypes are determined by two codominant alleles. A new rare variant B' has been detected in Japanese. Gene frequencies calculated from 304 individuals showed FXIII‐B A =0.735, FXIII‐B B = 0.252 and FXIII‐B B' = 0.013, respectively. The distribution of phenotypes fitted the Hardy‐Weinberg equilibrium.