Premium
Genetic heterogeneity of human prothrombin (FII)
Author(s) -
BOARD P. G.,
COGGAN M.,
PIDCOCK M. E.
Publication year - 1982
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1982.tb00689.x
Subject(s) - genetics , biology
SUMMARY A new procedure for the electrophoresis and localization of prothrombin is described. This technique has revealed three allelic variants at the prothrombin structural locus (FII). One of these alleles (F II 4 ) reaches polymorphic frequencies in some Pacific Island populations. Investigation of the activated products of the three variant prothrombins has demonstrated that, in each case, the structural variation is located on a profragment and not on the enzymically active thrombin molecule.