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δ‐aminolevulinate dehydrase: a new genetic polymorphism in man
Author(s) -
BATTISTUZZI G.,
PETRUCCI R.,
SILVAGNI L.,
URBANI F. R.,
CAIOLA S.
Publication year - 1981
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1981.tb00333.x
Subject(s) - phenotype , allele , genetics , biology , polymorphism (computer science) , allele frequency , gene , population , enzyme , biochemistry , medicine , environmental health
SUMMARY A method has been developed for the electrophoretic and quantitative analyses of human red cell δ‐aminolevulinate dehydrase (ALADH). The enzyme is under the control of an autosomal gene, with two common codominant alleles, ALADH 1 and ALADH 2 , with frequencies of 0–89 and Oil, respectively, in the Italian population. Mean phenotypic enzyme activities are nearly identical: 52, 49 and 55 mlU/g Hb for ALADH 1, 2‐1 and 2 phenotypes respectively.