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Epistasis effect: an alternative to the hypothesis of linkage disequilibrium in HLA associated diseases
Author(s) -
CLERGETDARPOUX F.,
BONAÏTIPELLIÉ C.
Publication year - 1980
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1980.tb00958.x
Subject(s) - linkage disequilibrium , epistasis , genetics , human leukocyte antigen , disequilibrium , biology , locus (genetics) , linkage (software) , major histocompatibility complex , genetic linkage , evolutionary biology , haplotype , gene , allele , medicine , antigen , ophthalmology
Summary Many studies on diseases associated with the major histocompatibility system rest on the hypothesis of a genetic susceptibility locus closely linked with the HLA complex in linkage disequilibrium. An alternative model is proposed which assumes an epistasis effect between the disease gene and the HLA system. Such a model is shown to give familial distribution which may simulate genetic linkage in a sample. The results are illustrated using data on insulin dependent diabetes.