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A cytogenetic study of 1000 spontaneous abortions
Author(s) -
HASSOLD T.,
CHEN N.,
FUNKHOUSER J.,
JOOSS T.,
MANUEL B.,
MATSUURA J.,
MATSUYAMA A.,
WILSON C.,
Yamane J. A.,
JACOBS P. A.
Publication year - 1980
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1980.tb00955.x
Subject(s) - biology , chromosome , genetics , trisomy , aneuploidy , abortion , population , cytogenetics , induced abortions , physiology , pregnancy , medicine , research methodology , gene , family planning , environmental health
Summary Cytogenetic analysis of 1000 spontaneous abortions showed 463 to have an abnormal chromosome constitution. The proportion of chromosome abnormalities varied with the gestational age of the abortus and the type of tissue cultured but was not significantly different among the five racial groups represented in the study population. It was suggested that differences in the rate of chromosome abnormalities among cytogenetic studies of spontaneous abortions were the result of methodological differences in sample selection rather than real biological variation among study populations. The only factor found to be unequivocally associated with the aetiology of chromosome abnormalities in spontaneous abortions was increasing maternal age in trisomies.