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The ‘singles’ method for segregation analysis under incomplete ascertainment
Author(s) -
DAVIE A. M.
Publication year - 1979
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1979.tb00683.x
Subject(s) - proband , simple (philosophy) , statistics , maximum likelihood , mathematics , genetics , biology , philosophy , epistemology , gene , mutation
Li & Mantel (1968) proposed a simple new method of segregation analysis under complete ascertainment. This paper shows that, with a slight modification, the method is also valid under incomplete ascertainment. The assumptions concerning ascertainment are discussed and the method compared with the maximum likelihood method and Weinberg's proband method.