Premium
Estimating distances from the centromere by means of benign ovarian teratomas in man
Author(s) -
OTT JURG,
LINDER DAVID,
McCAW BARBARA KAISER,
LOVRIEN EVERETT W.,
HECHT FREDERICK
Publication year - 1976
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1976.tb00179.x
Subject(s) - medical genetics , cancer genetics , medicine , gerontology , family medicine , library science , genetics , biology , computer science , gene
Under the assumption that benign ovarian teratomas in man arise parthenogenically from a germ cell by suppression of the second meiotic division, the distance of a gene from its centromere can be estimated from the observed proportion of heterozygous teratomas collected from heterozygous hosts. The frequency of heterozygous teratomas of heterozygous hosts is equivalent to the frequency of second division segregation at the gene locus which has been used for centromere-related mapping in fungal genetics for more than 40 years. Mapping functions useful for teratoma-based mapping in man are presented.