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The testing of dominants for heterozygosity
Author(s) -
LI C. C.
Publication year - 1976
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1976.tb00178.x
Subject(s) - inbreeding , loss of heterozygosity , mating , statistics , maximum likelihood , biology , simple (philosophy) , likelihood ratio test , mathematics , genetics , population , demography , gene , allele , philosophy , epistemology , sociology
A simple method of estimating the frequency of heterozygotes among the dominants by test-making has been described; and then a maximum likelihood estimate is obtained by an iterative counting procedure. Eearly results of Haldane have been review and modified. Methods of estimating the gene frequencies, their ratio, and the inbreeding coefficient from test-mating results have also been given.