Premium
Evidence for the assignment of the loci AK 1 , AK 3 and ACON s to chromosome 9 in man
Author(s) -
POVEY S.,
SLAUGHTER C. A.,
WILSON D. E.,
GORMLEY I. P.,
BUCKTON K. E.,
PERRY P.,
BOBROW M.
Publication year - 1976
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1976.tb00145.x
Subject(s) - galton's problem , population , unit (ring theory) , annals , cytogenetics , biochemistry , sociology , genealogy , chromosome , history , demography , biology , medicine , genetics , psychology , classics , pathology , mathematics , gene , statistics , mathematics education
The segregation of human enzymes and chromosomes has been studied in more than 30 independent primary human-rodent somatic cell hybrids and a series of 64 subclones. The results strongly suggest that the locus determining AK1, 'red cell' adenylate kinase, is on chromosome 9 in man, and hence that the locus for the ABO blood groups and that for the Nail-patella syndrome may also be assigned to this chromosome. Evidence is presented indicating that another adenylate kinase, nucleoside triphosphate adenylate kinase, and also the soluble form of aconitase, are probably syntenic with AK1, and that the mitochondrial form of aconitase is probably not syntenic with these loci.