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Bernstein's and gene‐counting methods in generalized ABO‐like systems
Author(s) -
NAM JUNMO,
CART JOHN J.
Publication year - 1976
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1976.tb00141.x
Subject(s) - estimator , abo blood group system , mathematics , statistics , efficiency , simple (philosophy) , combinatorics , genetics , biology , philosophy , epistemology
Summary Although the simple and adjusted Bernstein's methods are fully efficient for m = 2 and m = 3 (ABO system) respectively, their efficiency declines for larger values of m. For m 4, the adjusted or modified Bernstein's method with a single counting iteration leads to a nearly efficient estimator. A single degree of freedom chi‐square test of the Hardy‐Weinberg law for all m is derived. Some findings on the statistical efficiency of typing various numbers of antigens are given. All the results are illustrated in numerical examples.