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Adenylate kinases in man: evidence for a third locus
Author(s) -
WILSON D. E.,
POVEY SUSAN,
HARRIS HARRY
Publication year - 1976
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1976.tb00134.x
Subject(s) - isozyme , adenylate kinase , locus (genetics) , enzyme , biology , gtp' , biochemistry , microbiology and biotechnology , genetics , gene
Summary The tissue distribution of the adenylate kinase isozymes in man has been examined using various substrates. The isozymes attributable to the AK 1 and AK 2 loci were identified, and an additional set of isozymes probably attributable to a third locus was also found. This locus has been provisionally designated AK 3 . The AK 3 isozymes show activity with either GTP + AMP or ITP + AMP but do not show activity with ATP + AMP. They also differ from the AK 1 end AK 2 isozymes in electrophoretic mobility and from the AK 1 isozymes in being resistant to silver inhibition. They are similar in molecular size to the AK 1 isozymes whereas the AK 2 isozymes are apparently larger. The AK 3 isozymes evidently correspond to the enzyme nucleosidetriphosphate‐adenylate kinase (2.7.4.10).