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Alpha 1 antitrypsin phenotypes in Northern Ireland
Author(s) -
BLUNDELL GILLIAN,
FRAZER ASTRID,
COLE R. B.,
NEVIN N. C.
Publication year - 1975
Publication title -
annals of human genetics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1975.tb00612.x
Subject(s) - queen (butterfly) , citation , annals , library science , classics , history , biology , computer science , zoology , hymenoptera
Serum alpha1 antitrypsin levels and phenotypes were examined in 1000 healthy adults in Northern Ireland. The Pi phenotype M accounted for 87-8% Pi MS for 7-3% and Pi MZ for 3-5%. The percentages of the rarer phenotypes were Pi FM 0-3, Pi IM 0-6, Pi SZ 0-4 and Pi Z--0-1. The range of alpha1 antitrypsin levels in different phenotypes showed considerable overlap. Pi MS, Pi MZ and Pi SZ sera gave mean levels of 81%, 61% and 40% respectively of the mean level obtained in Pi M sera and that of the Pi Z--minus serum, 5%. Two distinct types of anomalous pattern were encountered in sera from ten subjects.