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Observations on the familial appearance of diseases associated with metabolic disorders of the mother
Author(s) -
RICHARDS B. W.
Publication year - 1975
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1975.tb00121.x
Subject(s) - annals , citation , stern , medicine , pediatrics , philosophy , classics , art , history , library science , computer science , ancient history
The familial appearnace of diseases in which a metabolic disorder of the mother causes foetal damage is examined and illustrated with typical pedigrees. The expected frequencies with which relatives of the probands are at risk are tabulated, and the effect of reduced maternal fertility is discussed. The familial appearance of disease is compared with that produced by maternal--foetal antigenic imcompatibility.