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D/D translocations in newborn children
Author(s) -
FRIEDRICH URSULA,
NIELSEN JOHANNES
Publication year - 1974
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1974.tb01997.x
Subject(s) - proband , chromosomal translocation , danish , medicine , obstetrics , genetics , demography , biology , mutation , linguistics , philosophy , sociology , gene
SUMMARY A family study has been made of seven unselected probands with 13/14 translocations found among 5049 consecutive liveborn children at a Danish maternity hospital. All cases were 13/14 translocations and all were familial. No individuals with unbalanced chromosome constitution were found in the seven families, and there was no information which might indicate the presence of individuals with Down's syndrome among the relatives. The segregation rate of carriers to normals did not deviate from unity. The frequency of abortions, stillbirths and infant mortality among the carriers was not significantly higher than among non‐carriers. Fertility among male carriers was comparatively low compared with female carriers and male carriers with normal chromosomes, but the difference was not significant. There was no indication of any increased risk of mental or physical disorders in carriers compared with normals.