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A study of parental age effects on the occurrence of fresh mutations for the Apert syndrome
Author(s) -
ERICKSON J. DAVID,
MICHAEL COHEN M.
Publication year - 1974
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1974.tb01996.x
Subject(s) - apert syndrome , paternal age , blank , biology , genetics , pediatrics , demography , medicine , pregnancy , mechanical engineering , craniosynostosis , sociology , offspring , engineering
SUMMARY A sample of 44 patients with the Apert syndrome was analysed for parental age effects on the occurrence of fresh mutations by using two conceptually similar techniques, one proposed by Smith (1972) and the other devised for the purposes of this study. The results of both analyses confirmed the parental age effect reported by Blank (1960), and was probably due solely to increased paternal age.