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The red cell 6‐phosphogluconate dehydrogenase polymorphism in certain Southern African populations; with the first report of a new phenotype
Author(s) -
JENKINS TREFOR,
NURSE G. T.
Publication year - 1974
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1974.tb01989.x
Subject(s) - allele , biology , genetics , allele frequency , polymorphism (computer science) , gene
SUMMARY1 Studies have been carried out on the 6‐phosphogluconate dehydrogenase polymorphism in over 3400 Southern Africans representing 34 distinct populations. The two commonest variant alleles, PGD C and PGD R , attain their highest known frequencies in the subcontinent. 2 It has been shown that while the very high frequency of PGD C found by previous workers in the Xhosa does not extend to the other South African Negro populations, the Dama of South West Africa have a frequency of PGD R high enough to be polymorphic. It is suggested that certain other populations possessing the PGD R allele may have obtained it from the Dama via the slave trade from Angola. 3 A new electrophoretic variant of GPG D , has been found in a member of the Kuanyama division of the Ambo peoples of South West Africa and has been named 6PGD Oshakati and the allele determining its synthesis PGD S .