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Additional data on the population distribution of human serum albumin genes; three new variants
Author(s) -
WEITKAMP L. R.,
McDERMID E. M.,
NEEL J. V.,
FINE J. M.,
PETRINI C.,
BONAZZI L.,
ORTALI V.,
PORTA F.,
TANIS R.,
HARRIS D. J.,
PETERS T.,
RUFFINI G.,
JOHNSTON E.
Publication year - 1973
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1973.tb01829.x
Subject(s) - population , annals , library science , medicine , demography , sociology , classics , history , computer science
Each albumin variant, its source, and ethnic origin are listed in the Appendix. Many of the new variants were found in several individuals in a single family. In other cases the variants were found in one or more individuals in a single village. The electrophoretic comparisons were made in the three starch-gel systems, acetate-EDTA at pH 5.0, tris-lithium-succinate-citrate at pH 6.0 and tris-EDTA-borate at pH 6.9, used previously (Weitkamp et al. 1973). RESULTS The results of the comparison of 30 new or recently described serum albumin variants with 20 variants previously distinguished using three starch-gel electrophoretic systems are presented in Table 1. Although the amount of separation reported here for the 20 variants previously described differs slightly from the earlier results, due to minor variations in electrophoretic conditions, the conclusions regarding their mobility relative to normal albumin and to each other remain the same. Three new variants, RS I, Xavante, and Yanomama-2, all slowly migrating, have been identified. Electropherograms showing these variants adjacent