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Genetics of haemoglobin H and α‐thalassaemia
Author(s) -
KOLER R. D.,
JONES R. T.,
WASI P.,
POOTRUKUL S.
Publication year - 1971
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1971.tb00249.x
Subject(s) - genetics , locus (genetics) , biology , allele , linkage (software) , population , thalassemia , genetic data , genetic linkage , evolutionary biology , medicine , gene , environmental health
SUMMARY Genetic models to describe the α‐thalassaemias are reviewed. Two of these, a one‐locus model with three alleles and a two‐loci model without linkage, are compared with population data from Thailand. Both models fit the observed data. Further tests are proposed to distinguish among these two and a third alternative, two linked a‐chain loci.