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A haptoglobin mating frequency, segregation and ABO blood‐group interaction analysis for additional series of families
Author(s) -
KIRK R. L.
Publication year - 1971
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1971.tb00245.x
Subject(s) - haptoglobin , abo blood group system , mating , offspring , mating type , series (stratigraphy) , biology , genetics , immunology , gene , pregnancy , paleontology
SUMMARY Data for a further eight series, comprising a total of 2349 families with 5701 tested children, has been analysed for evidence of disturbances in mating frequency, number of offspring and segregation with respect to haptoglobin type. Five of the series were examined also for interaction effects between the ABO blood‐group and haptoglobin systems. There was no significant departure from expectation for the frequency of matings in the haptoglobin system with the exception of the mating class Hp 1‐1 × 2‐1 in series no. 2. However, a comparison of the number of matings in the reciprocal mating classes 1‐1 × 2‐1 and 2‐1 × 1‐1 shows a significant excess of 2‐1 × 1‐1 matings. This excess is reflected even more in the number of children in the 2‐1 × 1‐1 mating class compared with the number in the reciprocal 1‐1 × 2‐1 class. There is a significant distortion in the Hp types of offspring in the Hp2‐1 × 2‐2 mating class for all series combined as well as for series nos. 1 and 8 considered individually, the Hp2‐1 offspring being in excess. Series no. 7 shows a deviation also, but in the opposite direction to that in the other series. A comparison of the Hp 1 gene frequencies among children born to parents who are classified as either compatible or incompatible for the ABO blood‐group system shows that the Hp 1 frequency is higher for the incompatible class in each of the five series for which information is available, the difference being significant in series nos. 2 and 3.