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Atypical segregation of human red cell acid phosphatase phenotypes: evidence for a rare ‘silent’ allele P o
Author(s) -
HERBICH J.,
FISHER E. A.,
HOPKINSON D. A.
Publication year - 1970
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1970.tb00228.x
Subject(s) - acid phosphatase , phenotype , allele , phosphatase , red cell , biology , genetics , cell , microbiology and biotechnology , alkaline phosphatase , enzyme , biochemistry , gene , medicine , phosphorylation
SUMMARY 1. Aberrant segregation of red cell acid phosphatase phenotypes has been encountered in a large family from Vienna. 2. The segregation data suggest the occurrence of a silent allele P o which is associated with either no acid phosphatase or very weak activity. 3. Quantitative analysis supports this interpretation since individuals who appear to be heterozygous for P o exhibit approximately half normal red cell acid phosphatase activity.