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Liver pyruvate kinase (PK) isozymes in a PK‐deficient patient *
Author(s) -
Bigley R. H.,
Koler R. D.
Publication year - 1968
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1968.tb00571.x
Subject(s) - isozyme , pyruvate kinase deficiency , pyruvate kinase , enzyme , biochemistry , chemistry , biology , glycolysis
SUMMARY Liver from a patient with hereditary haemolytic anaemia due to pyruvate kinase deficiency is a deficient in the ‘erythrocyte’ PK isozyme as are her erythrocytes. The chromatographic, electrophoretic, antigenic, heat stability and kinetic properties of the patient's enzyme were not different from normal.