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Variants of red cell ǵlucose‐6‐p‐hosphate dehydroǵenase amonǵ Asiatic Indians
Author(s) -
AZEVEDO ELIANE,
KIRKMAN H. NEIL,
MORROW ANNE C.,
MOTULSKY ARNO G.
Publication year - 1968
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1968.tb00569.x
Subject(s) - indian subcontinent , west bengal , electrophoresis , mediterranean climate , biology , north india , genetics , chemistry , ecology , ancient history , ethnology , socioeconomics , sociology , history
SUMMARY Among one hundfed and one unrelated Asiatic Indian males living in the Pacific north‐west, five G‐6‐PD‐deficient individuals were identified. The enzyme of three of these individuals was indistinguished elctrophoreticaly and biochemically from the Mediterranean type of deficiency . These individuals originated from the north‐western parts of the Indian subcontinent. The enzyme of one individual and that of his subsequently studied beother (G‐6‐PD Kerala) was found to be simialr to G‐6‐PD Seattle by k m G‐6‐P, k m TPN, pH optimum, utilization of 2d‐g‐6P and Gal‐6‐P and electrophoretic migration rate in Tris buffer, pH 8.8. Electrophoresis on TEB buffer (pH 8.6) however, showed this variant to be different from G‐6‐PD Seattle, The desirability of using multiple electrophoretic methods in the elucidation of new variants is emphasized by these observations. The third abmormal G‐6‐PD (G‐6‐PD West Bengal) was unlike other mutations previously described in having higher‐than normal k m TPN and lower‐than‐normal k m G‐6‐P and a slow electrophoretic mobilty. The identification of the Mediterranean type of G‐6‐PD deficiency in the north‐western part of the Indian subcontinent, together with histrorical and molecular considerations, suggests affiinities of Mediterranean, Near Eastern, and North‐west Indian populations.