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General purpose probability models in histocompatibility testing
Author(s) -
C. ELANDTJOHNSON REGINA
Publication year - 1968
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1968.tb00051.x
Subject(s) - locus (genetics) , allele , genetics , histocompatibility , biology , major histocompatibility complex , gene , human leukocyte antigen , antigen
Summary General probability models for finding the proportions of compatible and incompatible pairs donor‐recipient, in populations in equilibrium in respect of several histocompatibility loci, are derived. The cases when (i) all loci are only ‘strong’ or ‘weak’, (ii) some loci are ‘strong’, some ‘weak’, (iii) there are loci with ‘strong’ and ‘weak’ alleles at the same locus, (iv) combinations of (i), (ii) and (iii), are considered. Some of these cases are compared among themselves and with a single locus with multiple alleles, when only one gene dose, double gene dose or two different gene doses of antigen incompatibilities occur. A few models for populations of unrelated pairs, siblings and parent‐child combinations have been worked out numerically.