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Some complications of the use of the three‐generation method in the estimation of linkage relationships on the X chromosome in man
Author(s) -
FRASER G.R.
Publication year - 1968
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1968.tb00050.x
Subject(s) - linkage (software) , genetics , simple (philosophy) , genetic linkage , estimation , chromosome , value (mathematics) , biology , lod score , statistics , mathematics , evolutionary biology , gene mapping , gene , engineering , philosophy , systems engineering , epistemology
Summary The direct method of estimating linkage values between loci on the X chromosome based on families containing three generations (grandfather, mother, grandsons) is simple and satisfactory. Because some potentially informative families cannot be scored, however, under certain conditions of ascertainment, the proportion of recombinants among the grandchildren does not give rise to an unbiased estimate of the linkage value. The nature and extent of these biases are defined and it is shown that they are, in general, small. A simple method for their correction is outlined.