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Adenosine deaminase polymorphism in man
Author(s) -
SPENCER N.,
HOPKINSON D. A.,
HARRIS HARRY
Publication year - 1968
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1968.tb00044.x
Subject(s) - adenosine deaminase , isozyme , locus (genetics) , allele , biology , phenotype , genetics , microbiology and biotechnology , population , enzyme , biochemistry , gene , medicine , environmental health
Summary1 A new and specific method for the study of adenosine deaminase isozymes is described. 2 Examination of red‐cell lysates has revealed three genetically determined electrophoretically different ADA phenotypes: ADA 1, ADA 2–1 and ADA 2. 3 Family studies indicate that these phenotypes are determined by two alleles, ADA 1 and ADA 2 at an autosomal locus. 4 Preliminary population data suggest that ADA 2 has a frequency of about 0.06 in European, 0.04 in Negroes and 0.11 in Asiatic Indians. 5 The behaviour of the ADA isozyme pattern on storage or after treatment with thiol reagents suggests the occurrence of reactive sulphydryl groups in the enzyme molecules.