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Inheritance of marker chromosomes from a cytogenetic survey of congenital heart disease
Author(s) -
MOORES ELIZABETH C.,
ANDERS JANET M.,
EMANUEL RICHARD
Publication year - 1966
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1966.tb00008.x
Subject(s) - biology , genetics , inheritance (genetic algorithm) , chromosome , heart disease , population , disease , pathology , medicine , gene , environmental health
Summary The inheritance of marker chromosomes was investigated in six families found during a survey of 250 cases of congenital heart disease. Distinctive morphological variation was seen in chromosomes 9, 16, 17 and members of the 13–15 group. It was thought that the variation occurred at sites of secondary constrictions and was due to inherited alteration in behaviour of these hetero‐chromatic regions. In each family the marker chromosome was observed in two or more generations and was present in clinically normal relatives. They were similar to variants reported in the general population and were considered to be unrelated to congenital heart disease.