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Theoretical evidence for an autosomal modifying gene pair in glucose‐6‐phosphate dehydrogenase‐deficient families
Author(s) -
BOWMAN JAMES E.,
SMITH SHEILA MAYNARD
Publication year - 1963
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1963.tb01977.x
Subject(s) - pedigree chart , epistasis , genetics , gene , inheritance (genetic algorithm) , biology , phenotype , glucose 6 phosphate dehydrogenase , dehydrogenase , enzyme , biochemistry
SUMMARY1 Various glucose‐6‐phosphate dehydrogenase‐deficient pedigrees from the literature violating classical patterns of sex‐linked inheritance are reviewed and discussed. 2 It is suggested that anomalous phenotypes observed in these families may be the result of epistatic reactions between the effects of abnormal sex‐linked genes or gene and an autosomal pair.