Premium
A small autosomal ring chromosome in a female infant with congenital malformations
Author(s) -
LUCAS MARY,
KEMP N. H.,
ELLIS J. R.,
MARSHALL RUTH
Publication year - 1963
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1963.tb00212.x
Subject(s) - ring chromosome , congenital malformations , ring (chemistry) , genealogy , carr , empire , chromosome , mentally retarded , genetics , biology , karyotype , psychology , history , ancient history , gene , developmental psychology , chemistry , pregnancy , ecology , organic chemistry
SUMMARY A mentally retarded child with congenital malformations is described in whom a high proportion of cells contained a small ring chromosome derived from a no. 18 (Denver classification). The variability in the morphological appearance of the ring chromosome is illustrated and its stability is discussed in relation to other instances of ring chromosomes in both man and other organisms. The writers wish to thank Dr Margaret D. Baber and Dr Ursula James for their co‐operation during this investigation, Mr A. J. Lee for preparing the figures and Miss Penelope M. Carr, Miss Linda Z. Gorman and Miss Barbara J. Warland for technical assistance. Research grants from the British Empire Cancer Campaign (N.H.K.), from St George's Hospital (M.K.L.) and from the United States Public Health Service (RG‐6984) (J.R.E. and R.M.) made this study possible.