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The metabolism of methyl thiouracil and thiopentone in tasters and non‐tasters of P.T.C.
Author(s) -
EVANS D. A. PRICE,
KITCHIN F. D.,
RIDING J. E.
Publication year - 1962
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1962.tb01317.x
Subject(s) - taste , volunteer , thiouracil , chemistry , medicine , endocrinology , metabolism , urine , morning , food science , biochemistry , biology , thyroid , agronomy
Summary Volunteer subjects were given an oral dose of 15 mg. methyl thiouracil per kg. metabolically active mass (wt. 0–7 ). The urine was collected for 4 hr. thereafter and the percentage of the dose excreted in that time has been estimated. There is no indication of bimodality in the distribution of these percentages. The P.T.C. taste threshold titre has been assessed on thirty‐three of the subjects. There is no correlation between the P.T.C. taste titre and the percentage of the dose of methyl thiouracil recovered. Patients free of constitutional disease were given a dose of 20 mg. thiopentone per kg. metabolically active mass (wt. 0–7 ) intravenously. The plasma thiopentone concentration has been determined on blood taken from the opposite arm from that used for drug injection at 2, 5, 10 and 20 min. following drug injection. The patients' P.T.C. taste titres were determined. Analysis of the data reveals no significant differences in the 2 min. plasma thiopentone concentrations or in the fall of plasma thiopentone concentrations in tasters as compared with non‐tasters. The significance of the findings is discussed.