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Genetics of haemoglobin H
Author(s) -
KOLER ROBERT D.,
RIGAS DEMETRIOS A.
Publication year - 1961
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1961.tb01503.x
Subject(s) - genetics , trait , sibling , inheritance (genetic algorithm) , biology , family studies , gene , psychology , developmental psychology , computer science , programming language
Summary Additional studies are reported on the first family reported with haemoglobin H disease. These include the finding of a second fast minor haemoglobin in two of the subjects with haemoglobin H. This component does not have the alkaline resistance or ultra‐violet spectrum of foetal haemoglobin and is slower than Bart's haemoglobin on electrophoresis at pH 8‐6; it is, therefore, not Bart's haemoglobin. Another sibling has been studied and has thalassaemia trait. The current literature and hypotheses to explain the inheritance of haemoglobin H disease are reviewed.