Premium
A further genetically determined transferrin variant in man
Author(s) -
HARRIS H.,
PENINGTON D. G.,
ROBSON E. B.,
SCRIVER C. R.
Publication year - 1960
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1960.tb01745.x
Subject(s) - transferrin , phenotype , carbohydrate deficient transferrin , biology , gene , microbiology and biotechnology , chemistry , genetics , biochemistry , alcohol , alcohol consumption
Summary Two families are described in which a new transferrin variant D 4 is segregating. It has a mobility in starch gel electrophoresis at pH 8‐6 lower than that of transferrin C and higher than that of transferrin D v The fact that it is different from D 0 could be demonstrated using borate buffer, but not with the Tris/borate system. The familial distribution of the phenotype Tf CD 4 suggests that individuals of this phenotype are heterozygous for genes, one of which is necessary for the formation of transferrin C and the other for transferrin D 4 . There is no suggestion that transferrin D 4 is associated with any clinical abnormality, or with any other variation in serum protein formation. The frequency of the Tf CD 4 phenotype is approximately 1 in 625.