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The occurrence of two unusual serum protein phenotypes in a single pedigree
Author(s) -
Harris H.,
Lawler S. D.,
Robson E. B.,
SMITHIES O.
Publication year - 1959
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1959.tb01715.x
Subject(s) - transferrin , haptoglobin , phenotype , biology , genetics , inheritance (genetic algorithm) , gene , immunology , biochemistry
Summary A family is described in which two rare serum protein phenotypes are segregating. Some individuals possess, in addition to the usual transferrin ( β ‐globulin C ), an unusual transferrin B 2 , which has a higher mobility in starch gel electrophoresis. Such individuals of type TfB 2 C are distributed in the manner to be expected if they were heterozygous for a common gene determining transferrin C and a rare gene determining transferrin B 2 . A modified 2‐1 haptoglobin phenotype also occurs in two generations of this family. Some possible mechanisms of its inheritance are discussed.