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IRIS COLOUR IN PHENYLKETONURIA
Author(s) -
BERG J. M.,
STERN J.
Publication year - 1958
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1958.tb01431.x
Subject(s) - iris (biosensor) , ophthalmology , pigment , medicine , chemistry , computer security , organic chemistry , computer science , biometrics
Summary The iris colours of twenty‐six phenylketonurias at the Fountain Hospital were compared with those of a matched group of fifty‐two non‐phenylketonurics from the same hospital, by means of the ‘Martin Augen‐Farben Tafel’. A similar comparison was made of twelve of these phenylketonurias, from eleven families, and twenty‐three of their unaffected sibs. Iris colour of the phenylketonurics was found to be significantly lighter than that of the controls and unaffected sibs, although exceptions were noted in individual cases. The observed dilution is tentatively attributed to inhibition of pigment formation by the abnormal metabolites formed in phenylketonuria.