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IL1A ‐889 C/T gene polymorphism in irritant contact dermatitis
Author(s) -
Landeck L.,
Visser M.,
Kezic S.,
John S.M.
Publication year - 2013
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2012.04474.x
Subject(s) - medicine , dermatology , contact dermatitis , irritant contact dermatitis , polymorphism (computer science) , allergic contact dermatitis , gene , genetics , immunology , allergy , genotype , biology
Background Upon skin contact to irritants, interleukin‐1 alpha (IL‐1α) is released in the stratum corneum as a primary step of skin inflammation. Variations in the IL‐1A gene have been shown to alter the expression of IL‐1α. This may influence the susceptibility to skin inflammation and the development of irritant contact dermatitis (ICD). Objective To determine effects of an IL1A ‐889 C/T polymorphism in view of susceptibility to develop irritant contact dermatitis. Methods In a case–control study, 478 Caucasian patients with occupational ICD of the hands were genotyped for an IL1A ‐889 C/T polymorphism. Results were compared to 393 apprentices from the same high risk occupations (controls). Results Trends of a protective effect of the C→T transition at position IL1A ‐889 were seen (OR = 0.81; 95% CI: 0.65–1.00). The genotype distribution for IL1A ‐889 was 52.2% wild type (C/C), 39.2% heterozygous (C/T) and 8.6% homozygous for variant allele (T/T) in patients and 46.0%, 42.7% and 11.4% in controls. Subgroup analysis, which took into account atopy status and exposure, did not reveal a significant effect of this polymorphism for an aberrant risk to acquire for ICD. Conclusion Our study indicates a possible protective effect of the IL1A ‐889 C/T polymorphism regarding the development of ICD.