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Randomized, double‐blind, split‐side comparison study of moisturizer containing licochalcone vs. 1% hydrocortisone in the treatment of infantile seborrhoeic dermatitis
Author(s) -
Wananukul S.,
Chatproedprai S.,
Charutragulchai W.
Publication year - 2012
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2011.04187.x
Subject(s) - medicine , moisturizer , dermatology , rash , randomized controlled trial , hydrocortisone , double blind , surgery , pathology , chemistry , alternative medicine , food science , placebo
Background Infantile seborrhoeic dermatitis (ISD) is a common skin lesion in infants. There may be differences in recommendation for treatment of ISD. Objective To compare the efficacy of moisturizer containing licochalcone vs. 1% hydrocortisone for the treatment of ISD. Methods This was a randomized, prospective, split‐side, double‐blind study that was conducted in 75 infants between the age of 2 weeks and 1 year. Patients with a clinical diagnosis of ISD were treated twice daily, simultaneously with either moisturizer containing 0.025% licochalcone or 1% hydrocortisone on opposite sides of the lesion. The scoring system was used to assess the severity of the rash by the presence of erythema, scale and crusts. The lesions on each side were evaluated on day 0, 3–4, 6–7 and 14. Results A total of 72 patients completed the study. The moisturizer containing licochalcone group had a higher clearing rate (42%) compared to 1% hydrocortisone group (32%) ( P = 0.03) on day 3–4. Both products were equally effective in the treatment at day 6–7 and 14 ( P = 0.45 and 1, respectively). By the end of the second week, the cure rate of the moisturizer containing 0.025% licochalcone and 1% hydrocortisone group was 90% and 92%, respectively. Limitations The small sample size was a study limitation. Conclusion Moisturizer containing 0.025% licochalcone had higher cure rate compared to 1% hydrocortisone for the treatment of ISD at day 3–4. However, by the end of the first week, this difference was no longer significant.