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The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients
Author(s) -
Speeckaert R.,
Brochez L.,
Lambert J.,
van Geel N.,
Speeckaert M.M.,
Claeys L.,
Langlois M.,
Van Laer C.,
Peeters P.,
Delanghe J.R.
Publication year - 2012
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2011.04112.x
Subject(s) - haptoglobin , medicine , phenotype , skin cancer , transplantation , disease , cancer , gastroenterology , immunology , pathology , gene , biology , genetics
Background Cutaneous squamous cell carcinoma (SCC) is the most frequent skin cancer after organ transplantation. Currently, the pre‐identification of transplant patients at increased risk for non‐melanoma skin cancer remains difficult. Objective To investigate the Hp polymorphism as a marker for the identification of a subset of patients with an increased susceptibility to develop SCC/Bowen’s disease. Methods Haptoglobin phenotyping was performed with haemoglobin‐supplemented starch gel electrophoresis in 300 kidney transplant patients. High‐performance gel permeation chromatography was used in case of low serum haptoglobin concentration. Results Cox regression analysis (adjusted for age, gender and Mediterranean origin) showed a significant association of the Hp 1‐1 phenotype with a higher risk of SCC/Bowen’s disease ( P = 0.035) and multiple primary SCCs ( P = 0.002). No significant difference between the Hp phenotypes was found for the development of Bowen’s disease and SCCs in the first 10 years following renal transplantation. However, after a follow‐up of >10 years, a significant association between the Hp 1‐1 phenotype and the occurrence of Bowen’s disease and SCC was reported ( P = 0.002 and P = 0.001 respectively). Conclusions This study shows an increased risk for the development of (multiple) SCCs in kidney transplant patients with the Hp 1‐1 phenotype. This finding points to the role of Hp 1‐1 phenotype as an important predictor in identifying a subset of patients with an increased need for preventive measures and is in agreement with the decreased anti‐inflammatory capacity of this phenotype.