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Are port wines stains a feature of tuberous sclerosis?
Author(s) -
BenAmitai D.,
Halachmi S.,
Lapidoth M.
Publication year - 2011
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2010.03866.x
Subject(s) - tuberous sclerosis , medicine , port wine stain , dermatology , wine , stain , population , port (circuit theory) , pathology , port wine , staining , surgery , laser , physics , electrical engineering , environmental health , optics , engineering
Background Tuberous sclerosis complex is a multisystem inherited disorder characterized by the development of tumour‐like growths in brain, skin and other organs. Although cutaneous vascular anomalies are not considered a common manifestation, we have encountered co‐occurrence of port wine stains and tuberous sclerosis. Objective To assess the prevalence of port wine stain in patients with previously diagnosed tuberous sclerosis. Methods All cases diagnosed with tuberous sclerosis at two tertiary care centres from 2000 to 2009 were reviewed. Cases with clinically documented port wine stains were included for evaluation. Results Of 24 patients diagnosed with tuberous sclerosis, three (12.5%) had clinically evident port wine stains. The prevalence of port wine stains in this series of tuberous sclerosis patients was significantly higher than the 0.3% prevalence of port wine stain in the general population. Conclusion Port wine stain rate in this population was significantly greater than the expected rate. Further studies are needed to assess the frequency of port wine stains in tuberous sclerosis and to clarify whether the finding should be added to the list of cutaneous features of tuberous sclerosis.