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HPA‐suppressive effects of aqueous clobetasol propionate in the treatment of patients with oral lichen planus
Author(s) -
GonzalezMoles MA,
Scully C
Publication year - 2010
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2010.03591.x
Subject(s) - medicine , clobetasol propionate , stimulation , morning , maintenance therapy , acth stimulation test , adrenocorticotropic hormone , endocrinology , urology , gastroenterology , hormone , dermatology , corticosteroid , chemotherapy
Background Oral topical corticosteroids have potential to produce inhibition of the hypothalamus–pituitary–adrenal (HPA) axis. Objective To assess whether clobetasol propionate (CP) in aqueous solution causes HPA inhibition. Patients and methods Sixty‐two patients with oral lichen planus or oral lichenoid lesions presenting with severe lesions were treated with topical oral 0.05% CP plus 100 000 IU/cm 3 nystatin in aqueous solution. Initial treatment of three 5‐min mouthwashes (10 mL) daily was reduced, when the response was deemed complete or excellent, to a maintenance treatment of one 5‐min mouthwash on alternate days for 6 months; treatment was then withdrawn and patients were followed up for 1 year. HPA function was assessed by plasma cortisol measurement and adrenocorticotropin (ACTH) stimulation at the end of the initial and maintenance treatment regimens. Results The HPA axis was more frequently inhibited during initial (53/62; 85.5%) vs. maintenance (2/49; 4%) regimens of aqueous CP. Limitations In patients with morning plasma cortisol levels between 3 and 18 μg/dL, a normal result for the ACTH stimulation test only moderately reduces the possibility that a patient has secondary adrenal insufficiency. This can be considered a minor limitation in our study, as only three patients required additional assessment with the ACTH stimulation test. Conclusions Hypothalamus–pituitary–adrenal inhibition is substantial during initial treatment with aqueous CP three times daily.