Premium
Study on association between polymorphism of HLA‐DRB1 alleles and Behçet's disease
Author(s) -
Shang YB,
Zhai N,
Li JP,
Han SX,
Ren QS,
Song FJ,
Chen HD
Publication year - 2009
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2009.03335.x
Subject(s) - behcet's disease , medicine , erythema nodosum , allele , human leukocyte antigen , allele frequency , immunology , disease , polymorphism (computer science) , gastroenterology , antigen , gene , genetics , biology
Background Behçet's disease (BD) is known to be associated with human leucocyte antigen (HLA)‐B*51 in many ethnic groups. However, the association of HLA class II gene with BD has been described to be different according to different countries and regions. Objective This study aims to investigate the association between polymorphism of HLA‐DRB1 alleles and BD. Methods Forty patients with BD and 100 healthy controls were typed for HLA‐DRB1 alleles by the LABType TM SSO method. Results The frequency of HLA‐DRB1*14 was significantly higher in BD patients than in controls ( P < 0.05), while the frequency of HLA‐DRB1*15 was markedly lower in BD patients ( P < 0.05). Regarding clinical manifestations, the frequency of HLA‐DRB1*15 was significantly decreased in BD patients with genital ulcerations compared with controls ( P < 0.05); the frequency of HLA‐DRB1*14 was significantly increased in BD patients with erythema nodosum–like lesions and in BD patients with folliculitis‐like lesions when compared to controls ( P < 0.05, respectively). Moreover, the frequency of HLA‐DRB1*14 was significantly increased in BD patients under 20 years of age at the onset of disease ( P < 0.01), while the frequency of HLA‐DRB1*15 was significantly decreased in them ( P < 0.05), compared with controls. Conclusion The results suggested that HLA‐DRB1 alleles might play an important role in the onset and clinical manifestations of BD.