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Association between palmoplantar pustulosis and cigarette smoking in Brazil: a case–control study
Author(s) -
Miot HA,
Miot LDB,
Lopes PS,
Haddad GR,
Marques SA
Publication year - 2009
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2009.03282.x
Subject(s) - medicine , palmoplantar pustulosis , psoriasis , confounding , odds ratio , logistic regression , conditional logistic regression , case control study , dermatology
Background Palmoplantar pustulosis (PPP) discloses some differences compared to vulgar psoriasis (PV) in terms of age of onset, female predominance and low occurrence of psoriasis lesions elsewhere. Cigarette smoking has been associated to PPP in international studies; nevertheless, these studies were never performed among Brazilian. Objectives To compare prevalence of smoking among PPP, PV and other dermatologic patients (NPD). Methods Case–control study involving 25 PPP patients from a reference psoriasis centre. Two control groups were matched according to gender and age: 50 patients with PV and 50 NPD. Confounders were adjusted by conditional multiple logistic regression. Results Among cases, 84.0% were female and PPP age of disease onset (41.4 years) was greater than PV (34.5 years). Prevalence of ever smoking was higher among cases (92.0%) than PV (52.0%) and NPD (30.0%). Adjusted odds ratio of PPP ever smoking compared to PV and NPD was 9.5 and 36.2, respectively. All smokers reported the onset of their habit before the development of PPP. Conclusions There was significant association between PPP and smoking. However, the impact of giving it up in the clinical course of the disease remains to be established.