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Association between the PD1.3A/G polymorphism of the PDCD1 gene and systemic lupus erythematosus in European populations: a meta‐analysis
Author(s) -
Liu JL,
Zhang FY,
Liang YH,
Xiao FL,
Zhang SQ,
Cheng YL,
Yuan CD,
Chen QP,
Yang S,
Zhang XJ
Publication year - 2009
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2009.03087.x
Subject(s) - publication bias , meta analysis , odds ratio , medicine , confidence interval , funnel plot , allele , locus (genetics) , immunology , genetics , gene , biology
Background Linkage studies suggest a locus, SLEB2 , involved in susceptibility to systemic lupus erythematosus (SLE) and programmed cell death 1 ( PDCD1 ) gene locates in this region. The association of PDCD1 polymorphism (PD1.3A/G) with SLE has been widely investigated, but there are no unambiguous conclusions. Objective To assess the combined evidence for the association between PD1.3A/G polymorphism and SLE and to summarize the effect size of the polymorphism associated with susceptibility to SLE. Methods We surveyed studies on the PD1.3A/G polymorphism and SLE using comprehensive PubMed search up to May 2008. The pooled odds ratio (OR) was calculated using a fixed‐ or a random‐effects model. Heterogeneity was identified by sensitivity analysis and publication bias was examined by funnel plot and Egger's test. We also computed the power for a given number of samples. Results A total of 20 datasets from eight studies that met our inclusion criteria were included. The studies comprised of a total of 2909 cases and 3995 controls. Stratified meta‐analysis demonstrated a significant association between PD1.3A and SLE among non‐Spanish European descents [OR, 1.290; 95% confidence interval (95% CI), 1.098–1.516; z = 3.10, P = 0.002], while PD1.3G is the risk allele in Spanish populations (OR = 1.414, 95% CI = 1.075–1.862; z = 2.48, P = 0.013). Both results have sufficient power to support these findings. No publication bias presented in the studies analysed. Conclusions This meta‐analysis demonstrates a significant association between PD1.3A and SLE among non‐Spanish European descents, while a negative association was observed in Spanish population. Conflicts of interest None declared