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Tumour necrosis factor (TNF‐α) alpha converting enzyme and soluble TNF‐α receptor type 1 in psoriasis patients in relation to the chronic alcohol consumption
Author(s) -
Serwin AB,
Sokolowska M,
Dylejko E,
Chodynicka B
Publication year - 2008
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2008.02584.x
Subject(s) - psoriasis , medicine , tumor necrosis factor alpha , peripheral blood mononuclear cell , psoriasis area and severity index , cytokine , gastroenterology , receptor , alcohol consumption , immunology , alcohol , endocrinology , in vitro , biochemistry , biology
Background Tumour necrosis factor alpha converting enzyme (TACE) is a major sheddase of TNF‐α and its receptors, essential for the generation of soluble, mature molecules. The regulation of the TACE activity by ethanol in vitro has been suggested recently. The alcohol abuse is a frequent problem among psoriasis patients. The aim of the study was to analyse the relationship between long‐term alcohol consumption and the concentration of TACE in peripheral blood mononuclear cells (PBMC) and its substrate – soluble TNF‐α receptor type 1 (sTNF‐R1) in plasma in psoriasis patients. Methods The study has been conducted among 44 patients (aged 30–59 years) with early‐onset, plaque‐type psoriasis. Thirty‐eight patients (aged 29–61 years) with other than psoriasis chronic dermatologic disorders were controls. The data on alcohol consumption during previous 10 years were obtained with a structured questionnaire. The severity of the disease was assessed using Psoriasis Area and Severity Index (PASI), and concentrations of TACE in PBMC lysate and sTNF‐R1 in plasma was assessed with a quantitative sandwich enzyme immunoassay technique. Results The TACE concentration correlated to that of sTNF‐R1 ( R = 0.52 in psoriasis patients and R = 0.56 in controls, P < 0.05). The concentrations of TACE were 2.62 ± 0.32 ng/mL in patients and 1.29 ± 0.25 ng/mL in controls ( P < 0.05), and corresponding sTNF‐R1 concentrations were 2.54 ± 0.27 ng/mL and 1.79 ± 0.14 ng/mL ( P < 0.05), respectively. The concentrations of TACE and sTNF‐R1 in patients correlated to the intensity of alcohol consumption ( R = 0.56, and R = 0.52, P < 0.05, respectively) and were the highest in excessive drinking psoriasis patients (2.94 ± 0.34 and 2.67 ± 0.13 ng/mL). Conclusion The alcohol abuse may contribute to the increase of TACE expression in PBMC and also to the elevated plasma sTNF‐R1 concentration in psoriasis patients.