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High in vitro efficacy of Nyda ® L, a pediculicide containing dimeticone
Author(s) -
Oliveira FAS,
Speare R,
Heukelbach J
Publication year - 2007
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/j.1468-3083.2007.02258.x
Subject(s) - pediculosis , permethrin , medicine , malathion , toxicology , veterinary medicine , biology , horticulture , infestation , pesticide , ecology
Background The therapy of pediculosis remains a common problem in clinical practice. As resistance to commonly used chemical pediculicides is constantly increasing, there is a need for new effective compounds. Study design The efficacy of Nyda® L, a new pediculicide containing a high concentration of dimeticone, was assessed in an in vitro trial and compared with three reference products (Hedrin® containing 4% dimeticone, Lyclear® containing 1% permethrin, and Prioderm® containing 1% malathion) and a negative control group. Head lice were collected from heavily infested patients in a resource‐poor community in Northeast Brazil, where no resistance against pediculicides has been reported thus far. In each of the five groups, 50 adult fully vital lice were tested. We used a dip test (immersing head lice in the undiluted products for 3 min, washing off products after 20 min). Using predefined criteria for mortality, the lice were monitored at different points in time, for a period of 24 h. Results Nyda® L and Prioderm® killed all head lice already after 5 min. The efficacy of Nyda® L was better than of Lyclear®. Lice treated with Hedrin® resurrected after several hours and did not show a significantly higher mortality compared with the control group after 24 h. Conclusion Nyda® L can be regarded as a very efficacious pediculicidal compound, killing all lice in vitro within 5 min.